Secondary Plasma Cell Leukemia Life Expectancy

Given that actual treatment of spcl is unsatisfactory novel therapeutic approaches are needed in order to improve outcome and quality of life in these patients.

Secondary plasma cell leukemia life expectancy.

Men are at a slightly increased risk for developing plasma cell leukemia than women. Plasma cell leukemia is a rare and typically very aggressive form of blood cancer. When patients develop plasma cell leukemia after their original multiple myeloma it is secondary plasma cell leukemia. Traditionally pcl has been diagnosed based on kyle s criteria which requires circulating plasma cells to account for at least 20 of peripheral blood leukocytes and or an absolute circulating plasma cell count of 2 0 10 9 l with evidence of monoclonal gammopathy jimenez zepeda and dominguez 2006 some investigators consider this number to be arbitrary and have.

Normal plasma cells in the bone marrow produce antibodies that fight infection. Plasma cell leukemia pcl is a plasma cell dyscrasia i e. I had never had myeloma before it was my original diagnosis. I was diagnosed with primary plasma cell leukemia in 2012.

Plasma cell leukemia is more commonly seen in african americans than caucasians. A disease involving the malignant degeneration of a subtype of white blood cells called plasma cells it is the terminal stage and most aggressive form of these dyscrasias constituting 2 to 4 of all cases of plasma cell malignancies. It s often related closely to multiple myeloma and sometimes presents as a secondary form of this disease more often though it occurs all on its own which is usually known as a primary diagnosis. Plasma cell leukemia pcl is an aggressive form of multiple myeloma characterized by high levels of abnormal plasma cells circulating in the peripheral circulating blood.